Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer.

ABSTRACT:

Background

Diabetes mellitus and pancreatic cancer are intimately related. Our previous studies showed that high levels of blood glucose promote epithelial-mesenchymal transition of pancreatic cancer. In this study, we evaluated the relationship between hyperglycemia and hypoxic tumor microenvironments.

Methods

HIF-1α expression was evaluated by immunohistochemistry in clinical pancreatic cancer tissues with or without diabetes mellitus. Statistcal analysis was performed to explore the relationship between HIF-1α expression and pathological features of patients with pancreatic cancer. In vivo and in vitro models was established to detect whether a hyperglycemia environment could cause hypoxia in the pancreatic parenchyma and promote pancreatic cancer. In addition, we also te

SUBMITTER: Li W 

PROVIDER: S-EPMC6232646 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature