Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism.

ABSTRACT: Finding genetic variants that cause functional disruption or regulatory change among the many implicated GWAs variants remains a key challenge to translating the findings from GWAs to therapeutic treatments. Defining the causal mechanisms behind the variants require functional screening experiments that can be complex and costly. Prioritizing variants for functional characterization using techniques that capture important functional and regulatory elements can assist this. The genetic architecture of complex traits such as cardiovascular disease and type II diabetes comprise an enormously large number of variants of small effect contributing to heritability and spread throughout the genome. This makes it difficult to distinguish which variants or core genes are most relevant for prioritiza

SUBMITTER: Hughes MF 

PROVIDER: S-EPMC6232936 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature