Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.

ABSTRACT: Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes a range of diseases, including fatal invasive infections. However, the mechanisms by which the innate immune system recognizes GAS are not well understood. We herein report that the C-type lectin receptor macrophage inducible C-type lectin (Mincle) recognizes GAS and initiates antibacterial immunity. Gene expression analysis of myeloid cells upon GAS stimulation revealed the contribution of the caspase recruitment domain-containing protein 9 (CARD9) pathway to the antibacterial responses. Among receptors signaling through CARD9, Mincle induced the production of inflammatory cytokines, inducible nitric oxide synthase, and reactive oxygen species upon recognition of the anchor of lipoteichoic acid, monogluco

SUBMITTER: Imai T 

PROVIDER: S-EPMC6233082 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature