Assessing bone mineral changes in response to vitamin D supplementation using natural variability in stable isotopes of Calcium in Urine.

ABSTRACT: Osteoporosis is a chronic disease of public health importance, particularly in low and middle income countries. Measuring the bone mineral balance (BMB) in a non-invasive manner, and its response to different interventions, is critical to the definition of optimal strategies for its prevention and management. In this study, we demonstrate the usefulness of natural variability in calcium isotopes (δ^44/40Ca) of urine and the derived BMB estimates as a biomarker of bone health and its responsiveness to interventions. Vitamin D₃ is commonly used as a supplement for the prevention and treatment of osteoporosis, along with calcium supplements. We studied the effect of a short term vitamin D₃ supplementation on changes in urine δ^44/40Ca and the derived

SUBMITTER: Rangarajan R 

PROVIDER: S-EPMC6233152 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature