Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail.

ABSTRACT: The L strain of Japanese quail exhibits a plumage phenotype that is light yellowish in colour. In this study, we identified a nonsense mutation in the premelanosome protein (PMEL) gene showing complete concordance with the yellowish plumage within a pedigree as well as across strains by genetic linkage analysis of an F₂ intercross population using approximately 2,000 single nucleotide polymorphisms (SNPs) that were detected by double digest restriction site-associated DNA sequencing (ddRAD-seq). The yellowish plumage was inherited in an autosomal recessive manner, and the causative mutation was located within an 810-kb genomic region of the LGE22C19W28_E50C23 linkage group (LGE22). This region contained the PMEL gene that is required for the normal melanosome morphogenesis and e

SUBMITTER: Ishishita S 

PROVIDER: S-EPMC6233202 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature