Delineation of lung cancer with FDG PET/CT during radiation therapy.

ABSTRACT:

Objectives

To propose an easily applicable segmentation method (perPET-RT) for delineation of tumour volume during radiotherapy on interim fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with non-small cell lung cancer (NSCLC).

Material and methods

Sixty-seven patients (51 primary tumours, 60 lymph nodes), from 4 prospective studies, underwent an FDG PET/CT scan during the fifth week of radiation therapy, using different generations of PET/CT. Per-therapeutic PET/CT scans were delineated in consensus by two experienced physicians leading to the gold standard threshold to be applied. The mathematical expression of Th_opt, the optimal threshold to be applied as a function of the maximum standard uptake value

SUBMITTER: Ganem J 

PROVIDER: S-EPMC6233287 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature