Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial.

ABSTRACT:

Background

The Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction with MeD remained uncertain so far.

Methods

We carried out a study on a sample of 188 Italian subjects, analyzing their FTO rs9939609 alleles, and the difference in body composition between the baseline and a 4-weeks nutritional intervention. The sample was divided into two groups: the control group of 49 subjects, and the MeD group of 139 subjects.

Results

We found significant relations between MeD and both variation of total body fat (ΔTBFat) (p = 0.00) and gynoid body fat (p = 0.04). ∆TBFat (kg) demonstrated to have a significant relation with the inte

SUBMITTER: Di Renzo L 

PROVIDER: S-EPMC6233363 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature