Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies.

ABSTRACT:

Background

Genetic studies have reported contradictory results on the association between the intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and diabetic retinopathy (DR) risk in type 2 diabetic patients. We aimed to perform a systematic literature search and conduct random-effects meta-analysis to provide a quantitative evaluation.

Methods

We searched Pubmed, Embase, Scopus, Web of Science and Wanfang databases from inception up to January 2018. Allelic and genotype frequencies of rs5498 was compared between DR cases and controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using a random effects model.

Results

Nine studies involving a total of 1792 cases and 1400 controls met our inclusion criteria. We did not find any signific

SUBMITTER: Xie Z 

PROVIDER: S-EPMC6233373 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature