Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line.

ABSTRACT:

Background

Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer.

Methods

We investigated the anti tumor efficacy of triptolide in various pancreatic cancer cell lines (Capan-1, Capan-2, SNU-213, SNU-410, HPAFII, and Hs766T) and patient derived cells (PDCs) from metastatic pancreatic cancer patients.

Results

In vitro cell viability assay for triptolide in 6 PC cell lines, the IC₅₀ was 0.01 uM, 0.02 uM, 0.0096 uM for triptolide in Capan-1, Capan-2 and SNU-213. However, the growth of tumor cells was not significantly reduced by triptolide in Hs766T, SNU-410 and HPAFII. The d

SUBMITTER: Kim ST 

PROVIDER: S-EPMC6233492 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature