Dataset Information

Prevalence of Variant Reclassification Following Hereditary Cancer Genetic Testing.

ABSTRACT:

Importance

Variant reclassification is an important component of hereditary cancer genetic testing; however, there are few published data quantifying the prevalence of reclassification.

Objective

Retrospective cohort study of individuals who had genetic testing from 2006 through 2016 at a single commercial laboratory.

Design, setting, and participants

A retrospective cohort of individuals who had genetic testing between 2006 and 2016 at a single commercial laboratory was assessed. Variants were classified as benign, likely benign, variant of uncertain significance, likely pathogenic, or pathogenic. Retrospective chart reviews were conducted for patients from the University of Texas Southwestern (UTSW) Medical Center.