Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders.

ABSTRACT:

Importance

The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear.

Objective

To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders.

Design, setting, and participants

In this cross-sectional study, 719 participants were recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65.9% were amyloid-β [Aβ] positive [ie, MCI due to AD], 179 patients with AD dementia, and 254 patients with various non-AD neurod

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC6233630 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature