Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure.

ABSTRACT:

Importance

Mortality is high among patients heart failure (HF) who are receiving treatment, and therefore identifying new pathways rooted in preclinical cardiac remodeling phenotypes may afford novel biomarkers and therapeutic avenues. Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects relevant to myocardial biology, although large human investigations remain limited.

Objective

To measure the association of highly expressed circulating ex-RNAs with left ventricular remodeling and incident HF in a community-based cohort.

Design, setting, and participants

This is a prospective observational cohort study of individuals who were included in the eighth examination of the Framingham Offspring Cohort (2005-2008).

SUBMITTER: Shah RV 

PROVIDER: S-EPMC6233646 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature