Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice.

ABSTRACT:

Importance

Fluoroquinolones are among the most commonly prescribed antibiotics. Recent clinical studies indicated an association between fluoroquinolone use and increased risk of aortic aneurysm and dissection (AAD). This alarming association has raised concern, especially in patients with AAD with risk of rupture and in individuals at risk for developing AAD.

Objective

To examine the effect of ciprofloxacin on AAD development in mice.

Design, setting, and participants

In a mouse model of moderate, sporadic AAD, 4-week-old male and female C57BL/6J mice were challenged with a high-fat diet and low-dose angiotensin infusion (1000 ng/min/kg). Control unchallenged mice were fed a normal diet and infused with saline. After randomization, challenged and unchallenged mice re

SUBMITTER: LeMaire SA 

PROVIDER: S-EPMC6233654 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature