Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas.

ABSTRACT:

Background

Transplantation of beta cells by pancreas or islet transplantation is the treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus. Pancreata are frequently not accepted for transplantation, because of the relatively high vulnerability of these organs to ischemic injury. In this study, we evaluated the effects of hypothermic machine perfusion (HMP) on the quality of human pancreas grafts.

Methods

Five pancreata derived from donation after circulatory death (DCD) and 5 from donation after brain death (DBD) donors were preserved by oxygenated HMP. Hypothermic machine perfusion was performed for 6 hours at 25 mm Hg by separate perfusion of the mesenteric superior artery and the splenic artery. Results were compared with those of 10

SUBMITTER: Leemkuil M 

PROVIDER: S-EPMC6233671 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature