Anhedonia in Trauma-Exposed Individuals: Functional Connectivity and Decision-Making Correlates.

ABSTRACT:

Background

Reward processing deficits have been increasingly associated with trauma exposure and are a core feature of posttraumatic stress disorder (PTSD). While altered resting-state functional connectivity (rsFC) of ventral striatal regions, including the nucleus accumbens (NAcc), has been associated with anhedonia in some stress-related disorders, relationships between NAcc rsFC and anhedonia have not previously been investigated in trauma-exposed individuals. Additionally, relationships between anhedonia and reward-related decision making remain unexplored in relation to trauma exposure. We hypothesized that elevated anhedonia would be associated with altered rsFC between NAcc and default mode network regions and with increased delay discounting.

Methods

The sample incl

SUBMITTER: Olson EA 

PROVIDER: S-EPMC6233731 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature