Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature.

ABSTRACT:

Importance

To date, there is no diagnostic test for Kawasaki disease (KD). Diagnosis is based on clinical features shared with other febrile conditions, frequently resulting in delayed or missed treatment and an increased risk of coronary artery aneurysms.

Objective

To identify a whole-blood gene expression signature that distinguishes children with KD in the first week of illness from other febrile conditions.

Design, setting, and participants

The case-control study comprised a discovery group that included a training and test set and a validation group of children with KD or comparator febrile illness. The setting was pediatric centers in the United Kingdom, Spain, the Netherlands, and the United States. The training and test discovery group comprised 404 children w

SUBMITTER: Wright VJ 

PROVIDER: S-EPMC6233768 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature