Maintenance Treatment and Survival in Patients With Myeloma: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

Several trials demonstrated the impact of novel agent-based maintenance in newly diagnosed multiple myeloma (NDMM), but there is no current evidence demonstrating the superiority of one regimen over the other, owing to the lack of direct/indirect comparisons.

Objective

To analyze and compare the effectiveness of different maintenance regimens in NDMM via a network meta-analysis.

Data sources

We performed 2 independent searches in PubMed and Cochrane databases, and then we identified all the records registered after 1999 and on or before November 20, 2017.

Study selection

By blinded review, we identified prospective phase 3 randomized trials evaluating novel agent-based maintenance in patients with NDMM; the included studies compared at least 2 mainte

SUBMITTER: Gay F 

PROVIDER: S-EPMC6233774 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature