Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration.

ABSTRACT:

Importance

Immunization with tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is recommended in the United States during weeks 27 through 36 of pregnancy to prevent life-threatening infant pertussis. The optimal gestation for immunization to maximize concentrations of neonatal pertussis toxin antibodies is unknown.

Objective

To determine pertussis toxin antibody concentrations in cord blood from neonates born to women immunized and unimmunized with Tdap vaccine in pregnancy and optimal gestational age for immunization to maximize concentrations of neonatal antibodies.

Design, setting, and participants

Prospective, observational, cohort study of term neonates in Houston, Texas (December 2013-March 2014).

Exposures

Tdap immunization during weeks 27 thr

SUBMITTER: Healy CM 

PROVIDER: S-EPMC6233794 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature