Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing.

ABSTRACT:

Importance

Psychoticlike experiences (PLEs) are subclinical manifestations of psychotic symptoms and may reflect an increased vulnerability to psychotic disorders. Contemporary models of psychosis propose that dysfunctional reward processing is involved in the cause of these clinical illnesses.

Objective

To examine the neuroimaging profile of healthy adolescents at 14 and 19 years old points with PLEs, using a reward task.

Design, setting, and participants

A community-based cohort study, using both a cross-sectional and longitudinal design, was conducted in academic centers in London, Nottingham, United Kingdom, and Dublin, Ireland; Paris, France; and Berlin, Hamburg, Mannheim, and Dresden, Germany. A group of 1434 healthy adolescent volunteers was evaluated, and 2 su

SUBMITTER: Papanastasiou E 

PROVIDER: S-EPMC6233806 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature