Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.

ABSTRACT:

Importance

Major warfarin-related bleeding occurs more frequently in African Americans than in other populations. Identification of potential genetic factors related to this adverse event may help identify at-risk patients.

Objective

To identify genetic factors associated with warfarin-related bleeding in patients of African descent at an international normalized ratio (INR) of less than 4.

Design, setting, and participants

A case-control genome-wide association study involving patients of African descent taking warfarin was conducted in a discovery cohort (University of Chicago [2009-2011] and the University of Illinois at Chicago [2002-2011]), and associations were confirmed in a replication cohort (University of Chicago [2015-2016]). Potential population stratifica

SUBMITTER: De T 

PROVIDER: S-EPMC6233811 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature