Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.

ABSTRACT:

Importance

The prevalence of nonischemic dilated cardiomyopathy (DCM) is greater in individuals of African ancestry than in individuals of European ancestry. However, little is known about whether the difference in prevalence or outcomes is associated with functional genetic variants.

Objective

We hypothesized that Bcl2-associated anthanogene 3 (BAG3) genetic variants were associated with outcomes in individuals of African ancestry with DCM.

Design

This multicohort study of the BAG3 genotype in patients of African ancestry with dilated cardiomyopathy uses DNA obtained from African American individuals enrolled in 3 clinical studies: the Genetic Risk Assessment of African Americans With Heart Failure (GRAHF) study; the Intervention in Myocarditis and Acute Cardiomyopat

SUBMITTER: Myers VD 

PROVIDER: S-EPMC6233818 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature