Commercial Claims-Based Comparison of Survival and Toxic Effects of Definitive Radiotherapy vs Primary Surgery in Patients With Oropharyngeal Squamous Cell Carcinoma.

ABSTRACT:

Importance

Definitive radiotherapy (RT) and primary surgery (PS) are considered to be equally viable local therapy modalities for oropharyngeal squamous cell carcinoma (OPSCC). The comparative effectiveness of these therapies is often debated, and treatment decisions are based on a paucity of comparative data.

Objective

To examine the differences in overall survival and key toxic effects in patients with OPSCC treated with RT and PS.

Design, setting, and participants

This retrospective cohort analysis used the HealthCore Integrated Research Database to identify 884 patients diagnosed with OPSCC from January 1, 2007, to December 31, 2014. Patients were categorized as receiving definitive RT (with or without chemotherapy) or PS (with or without adjuvant RT or chemoradio

SUBMITTER: Sher DJ 

PROVIDER: S-EPMC6233826 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature