Role of the Complement System in Chronic Central Serous Chorioretinopathy: A Genome-Wide Association Study.

ABSTRACT:

Importance

To date, several targeted genetic studies on chronic central serous chorioretinopathy (cCSC) have been performed; however, unbiased genome-wide studies into the genetics of cCSC have not been reported. To discover new genetic loci associated with cCSC and to better understand the causative mechanism of this disease, we performed a genome-wide association study (GWAS) on patients with cCSC.

Objective

To discover new genetic loci and pathways associated with cCSC and to predict the association of genetic variants with gene expression in patients with cCSC.

Design, setting, and participants

This case-control GWAS was completed in the general community, 3 referral university medical centers, and outpatient care on Europeans individuals with cCSC and population-

SUBMITTER: Schellevis RL 

PROVIDER: S-EPMC6233836 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature