Association of Uveal Melanoma Metastatic Rate With Stochastic Mutation Rate and Type of Mutation.

ABSTRACT:

Importance

It is necessary to understand the mechanisms of metastasis of uveal melanoma to advise patients and develop treatments for this tumor.

Objective

To examine the stochastic properties of primary uveal melanoma including the mutation rate as a function of tumor size and metastatic rate relative to the type of mutation.

Design, setting, and participants

We computed the mutation rate in different sized uveal melanomas using previously published large data sets. Tumor volume was estimated using the spherical cap method. We also calculated the metastatic rate using an updated data set of patients with uveal melanoma with known mutations in BAP1, SF3B1, and EIF1AX provided by the Rotterdam Ocular Melanoma Study Group. Data were analyzed from 2 studies, one taking p

SUBMITTER: Szalai E 

PROVIDER: S-EPMC6233840 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature