Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography.

ABSTRACT:

Importance

Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia.

Objective

To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people.

Design, setting, and participants

UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. The pilot study phase was conducted from March 2006 to June 2006, and the main cohort underwent examination for baseline measures from April 2007 to October 2010. Fo

SUBMITTER: Ko F 

PROVIDER: S-EPMC6233846 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature