Assessing Biological and Methodological Aspects of Brain Volume Loss in Multiple Sclerosis.

ABSTRACT:

Importance

Before using brain volume loss (BVL) as a marker of therapeutic response in multiple sclerosis (MS), certain biological and methodological issues must be clarified.

Objectives

To assess the dynamics of BVL as MS progresses and to evaluate the repeatability and exchangeability of BVL estimates with Jacobian Integration (JI) and Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL) (specifically, the Structural Image Evaluation, Using Normalisation, of Atrophy-Cross-Sectional [SIENA-X] tool or FMRIB's Integrated Registration and Segmentation Tool [FIRST]).

Design, setting, and participants

A cohort of patients who had either clinically isolated syndrome or MS was enrolled from February 2011 through October 2015. All underwent a ser

SUBMITTER: Andorra M 

PROVIDER: S-EPMC6233851 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature