Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging.

ABSTRACT:

Importance

Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity.

Objective

To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length.

Design, setting, and participants

In a prospective birth cohort (ENVIRONAGE [Environmental Influence on Ageing in Early Life]), a total of 730 mother-newborn pairs were recruited in Flanders, Belgium between February 2010 and December

SUBMITTER: Martens DS 

PROVIDER: S-EPMC6233867 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature