18F-Fluorosulfate for PET Imaging of the Sodium-Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo.

ABSTRACT: Anion transport by the human sodium-iodide symporter (hNIS) is an established target for molecular imaging and radionuclide therapy. Current radiotracers for PET of hNIS expression are limited to ¹²⁴I^- and ¹⁸F-BF₄^- We sought new ¹⁸F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radiochemical synthesis than ¹⁸F-BF₄^- METHODS: The ability of a range of anions, some containing fluorine, to block ^99mTcO₄^- uptake in hNIS-expressing cells was measured. SO₃F^- emerged as a promising candidate. ¹⁸F-SO₃F^- was synthesized by reaction of ¹⁸F^- with SO₃

SUBMITTER: Khoshnevisan A 

PROVIDER: S-EPMC6233868 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature