Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.

ABSTRACT: A unique chemically induced proximity method is engineered based on mutant antibody VL domain using a fluorogenic malachite green derivative as the inducer, which gives fluorescent signals upon VL domain dimerization while simultaneously inducing downstream biological effects.

SUBMITTER: Zeng G 

PROVIDER: S-EPMC6233874 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature