(Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster.

ABSTRACT: We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy-to-handle KF(18 F). The reactions exhibited high functional-group tolerance and needed only an ambient atmosphere. This 18 F addition to C-C unsaturated bonds proceeded with extraordinarily high radiochemical yields.

SUBMITTER: Zeng X 

PROVIDER: S-EPMC6233894 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature