Deleterious variation shapes the genomic landscape of introgression.

ABSTRACT: While it is appreciated that population size changes can impact patterns of deleterious variation in natural populations, less attention has been paid to how gene flow affects and is affected by the dynamics of deleterious variation. Here we use population genetic simulations to examine how gene flow impacts deleterious variation under a variety of demographic scenarios, mating systems, dominance coefficients, and recombination rates. Our results show that admixture between populations can temporarily reduce the genetic load of smaller populations and cause increases in the frequency of introgressed ancestry, especially if deleterious mutations are recessive. Additionally, when fitness effects of new mutations are recessive, between-population differences in the sites at which deleterious

SUBMITTER: Kim BY 

PROVIDER: S-EPMC6233928 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature