Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction.

ABSTRACT: Air pollution is a diverse and dynamic mixture of gaseous and particulate matter, limiting our understanding of associated adverse health outcomes. The biological effects of two simulated smog atmospheres (SA) with different compositions but similar air quality health indexes were compared in a nonobese diabetic rat model (Goto-Kakizaki, GK) and three mouse immune models (house dust mite (HDM) allergy, antibody response to heat-killed pneumococcus, and resistance to influenza A infection). In GK rats, both SA-PM (high particulate matter) and SA-O₃ (high ozone) decreased cholesterol levels immediately after a 4-h exposure, whereas only SA-O₃ increased airflow limitation. Airway responsiveness to methacholine was increased in HDM-allergic mice compared with nonallergic

SUBMITTER: McGee Hargrove M 

PROVIDER: S-EPMC6233996 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature