Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.

ABSTRACT: Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the fruit fly as powerful model system to study the neural circuits of CrebB-dependent appetitive olfactory LTM. We edited the CrebB locus to create a GFP-tagged CrebB conditional knockout allele, allowing us to generate mutant, post-mitotic neurons with high spatial and temporal precision. Investigating CrebB-dependence within the mushroom body (MB) circuit we show that MB α/β and α'/β' neurons

SUBMITTER: Widmer YF 

PROVIDER: S-EPMC6234028 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature