Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV.

ABSTRACT:

Objective

HIV-associated neurocognitive disorder (HAND) occurs in a significant percentage of HIV-infected (HIV+) adults. Increased intraindividual variability (IIV) in cognitive function may be an early marker of emerging neurocognitive disorder, which suggests that IIV may be a sensitive measure of neurologic compromise in HIV. In the current study, we hypothesize that increased IIV may predict impending morbidity, including future cognitive decline and death.

Method

In 708 HIV+ participants followed longitudinally for up to 14 years, we assessed the role of dispersion in forecasting death and cognitive decline. Incident neurocognitive impairment was predicted in a mixed-effects ordinal logistic regression model using age, gender, baseline mean cognitive functioning, CD4+,

SUBMITTER: Anderson AE 

PROVIDER: S-EPMC6234088 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature