GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.

ABSTRACT:

Background

Advances in deep sequencing technology have uncovered a widespread, protumorigenic role of guanine nucleotide-binding (G protein) α (GNA) subunits, particularly GNA subunits Gs (GNAS), Gq (GNAQ), and G11 (GNA11) (GNA*), in a diverse collection of malignancies. The objectives of the current study were: 1) to determine GNA* aberration status in a cohort of 1348 patients with cancer and 2) to examine tumor mutational burden, overall survival rates, and treatment outcomes in patients with GNA*-positive tumors versus those with tumors that had wild-type GNA*.

Methods

For each patient, clinical and genomic data were collected from medical records. Next-generation sequencing was performed for each patient (range, 182-236 genes).

Results

Aberrations of GNA* genes w

SUBMITTER: Parish AJ 

PROVIDER: S-EPMC6234097 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature