Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice.

ABSTRACT: Erythropoietin (EPO) has been shown to improve cognitive function in mammals as well as in patients of psychiatric diseases by directly acting on the brain. In addition, EPO attenuates the synaptic transmission and enhances short- and long-term synaptic plasticity in hippocampus of mice, although there are still many discrepancies between different studies. It has been suggested that the divergences of different studies take root in different in-vivo application schemata or in long-term trophic effects of EPO. In the current study, we investigated the direct effects of EPO in slices of prelimbic cortex (PrL) by acute ex-vivo application of EPO, so that the erythropoietic or other trophic effects could be entirely excluded. Our results showed that the EPO effects were contradi

SUBMITTER: Dik A 

PROVIDER: S-EPMC6234276 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature