Neuroendocrine and neuroimmune adaptation to Chronic Escalating Distress (CED): A novel model of chronic stress.

ABSTRACT: Acute and chronic stress challenges have a profound influence on the development and expression of subsequent affective disorders, alcohol use disorders, and natural aging processes. These experiments examined adaptation in neuroimmune and neuroendocrine responses that occurred as a result of exposure to a novel model of chronic stress, termed chronic escalating distress (CED). This model involves exposure to highly predictable daily stress challenges involving a systematic escalation in both the intensity and length of daily stress challenges, and has recently been shown to profoundly alter alcohol sensitivity. Male Sprague-Dawley rats were exposed to an 11 day procedure where days 1-5 consisted of 60  min of restraint, days 6-10 consisted of 60  min of restraint immediately followed by 3

SUBMITTER: Lovelock DF 

PROVIDER: S-EPMC6234279 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature