CD16⁺ monocytes give rise to CD103⁺RALDH2⁺TCF4⁺ dendritic cells with unique transcriptional and immunological features.

ABSTRACT: Classical CD16^- vs intermediate/nonclassical CD16⁺ monocytes differ in their homing potential and biological functions, but whether they differentiate into dendritic cells (DCs) with distinct contributions to immunity against bacterial/viral pathogens remains poorly investigated. Here, we employed a systems biology approach to identify clinically relevant differences between CD16⁺ and CD16^- monocyte-derived DCs (MDDCs). Although both CD16⁺ and CD16^- MDDCs acquire classical immature/mature DC markers in vitro, genome-wide transcriptional profiling revealed unique molecular signatures for CD16⁺ MDDCs, including adhesion molecules (ITGAE/CD103), transcription factors (TCF7L2/TCF4), and enzymes (ALDH1A2/RALDH2), where

SUBMITTER: Wacleche VS 

PROVIDER: S-EPMC6234376 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature