Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group.

ABSTRACT:

Background/aims

Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytokine polymorphisms and AP as pilot research in a Korean ethnic group.

Methods

Patients who had been diagnosed with AP were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Single-nucleotide polymorphisms (SNPs) of the interleukin 1β (IL1B), interleukin 1 receptor antagonist (IL1RN), and tumor necrosis factor α (TNFA) genes of patients with AP were compared to those of normal controls.

Results

Between January 2011 and Jan

SUBMITTER: Park JW 

PROVIDER: S-EPMC6234396 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature