Ontology highlight
ABSTRACT:
SUBMITTER: Maksymiuk AW
PROVIDER: S-EPMC6234463 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Future science OA 20180910 10
<h4>Aim</h4>SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.<h4>Results</h4>High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.<h4>Conclusion</h4 ...[more]