Dataset Information
Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer.
Ontology highlight
ABSTRACT: Aim
SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.Results
High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.Conclusion
Increases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmation/quantification. The high levels of acetylated amantadine could be used as a simple and useful screening test for the presence of cancer.
SUBMITTER: Maksymiuk AW
PROVIDER: S-EPMC6234463 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Spermidine/spermine <i>N1</i>-acetyltransferase-1 as a diagnostic biomarker in human cancer.
Future science OA 20180910 10
<h4>Aim</h4>SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.<h4>Results</h4>High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.<h4>Conclusion</h4 ...[more]
