In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [¹⁸F]DPA714 PET.

ABSTRACT:

Background

Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflammation, in vivo. The second generation PET radioligand [¹⁸F]DPA714 binds with high affinity to the 18-kDa translocator-protein (TSPO), which is mainly expressed on activated microglia. The aim of this proof of concept study was to evaluate this in vivo marker of neuroinflammation in primary and secondary progressive MS.

Methods

All subjects were genotyped for the rs6971 polymorphism within the TSPO gene, and low-affinity binders were excluded from participation in this study. Eight patients with progressive MS and seven age and

SUBMITTER: Hagens MHJ 

PROVIDER: S-EPMC6234549 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature