HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.

ABSTRACT:

Background

In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF.

Methods

Using a mouse eccentric limb injury model, we characterized the protective effects of prolyl hydroxylase inhibitor, GSK1120360A. We then extended these studies to

SUBMITTER: Billin AN 

PROVIDER: S-EPMC6234580 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature