Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice.

ABSTRACT:

Background

Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS.

Results

Here we show that gut microbiome mediates the preventive effect of estrogen (17β-estradiol) on metabolic endotoxemia (ME) and low-grade chronic inflammation (LGCI), the underlying causes of MS and chronic diseases. The characteristic profiles of gut microbiome observed in female and 17β-estradiol-treated male and ovariectomized mice, such as decreased Proteobacteria and lipopolysaccharide biosynthesis, were associated with a lower susceptibility to ME, LGCI, and MS in these animals. Interestingly, fecal microbiota-transplant from male mice transferred the MS phenotype to female mic

SUBMITTER: Kaliannan K 

PROVIDER: S-EPMC6234624 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature