Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.

ABSTRACT:

Background

Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine whether TLR8 and TLR9 SNPs were associated with the development of latent TB infection (LTBI) and the subsequent pulmonary TB (PTB) in a Chinese Han population.

Methods

Two independent samples were enrolled. The first sample contained 584 TB cases and 608 controls; the second sample included 204 healthy controls, 201 LTBI subjects and 209 bacteria-confirmed active PTB patients. Three SNPs (rs3764880, rs187084 and rs5743836) were genotyped. The associations between the SNPs and risk of LTBI or PTB were investigated using unconditional logistic regression ana

SUBMITTER: Wang MG 

PROVIDER: S-EPMC6234681 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature