Tropism of mesenchymal stem cell toward CD133⁺ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo.

ABSTRACT:

Background

Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated glioblastoma (GBM) cells. However, the potential contribution of MSCs to tumor progression is a matter of concern. It has been suggested that CD133⁺ GBM stem cells secrete a variety of chemokines, including monocytes chemoattractant protein-1 (MCP-1/CCL2) and stromal cell-derived factor-1(SDF-1/CXCL12), which could act in this tropism. However, the role in the modulation of this tropism of the subpopulation of CD133⁺ cells, which initiate GBM and the mechanisms underlying the tropism of MSCs to CD133⁺ GBM cells and their effects on tumor d

SUBMITTER: Pavon LF 

PROVIDER: S-EPMC6234773 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature