Development of a peptide targeting dopamine transporter to improve ADHD-like deficits.

ABSTRACT: Attention-deficit hyperactivity disorder (ADHD) is a neurocognitive disorder characterized by hyperactivity, inattention, working memory deficits and impulsivity. Its worldwide prevalence is estimated to be 3-5% in children and adolescents. The mainstay treatment for ADHD is stimulant medications (e.g. methylphenidate), which increase synaptic dopamine by directly blocking dopamine transporter (DAT). Although these pharmacological agents are effective, they are often associated with various side effects including risks for future substance use disorders in ADHD patients. Here, we investigated an interaction between DAT and dopamine D2 receptor (D2R) as a novel target to develop potential therapeutics for the treatment of ADHD by using an interfering peptide (TAT-DAT_NT) to dissoc

SUBMITTER: Lai TKY 

PROVIDER: S-EPMC6234781 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature