MRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.

ABSTRACT: N⁶-methyladenosine (m⁶A) modification of mRNA is emerging as an important regulator of gene expression that affects different developmental and biological processes, and altered m⁶A homeostasis is linked to cancer^1-5. m⁶A modification is catalysed by METTL3 and enriched in the 3' untranslated region of a large subset of mRNAs at sites close to the stop codon⁵. METTL3 can promote translation but the mechanism and relevance of this process remain unknown¹. Here we show that METTL3 enhances translation only when tethered to reporter mRNA at sites close to the stop codon, supporting a mechanism of mRNA looping for ribosome recycling and translational control. Electron microscopy reveals the topology of individual poly

SUBMITTER: Choe J 

PROVIDER: S-EPMC6234840 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature