Overexpression of RALY promotes migration and predicts poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Introduction

RALY plays a critical role in promoting invasiveness and is associated with poor prognosis in different types of cancers. However, the prognostic value of RALY and its precise role in hepatocellular carcinoma (HCC) remain unknown.

Materials and methods

We detected the expression of RALY in 127 clinical HCC tissue samples and seven HCC cell lines by immunohistochemical staining and Western blotting. The prognostic value of RALY expression was assessed using the Kaplan-Meier method. The expression and prognostic value of RALY were also studied by bioinformatics analysis of data from the Gene Expression Omnibus and The Cancer Genome Atlas. The biological influence of RALY on HCC cell lines was studied using proliferation, transwell migration, and invasion assays in

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC6235007 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature