Ontology highlight
ABSTRACT:
SUBMITTER: Karatepe K
PROVIDER: S-EPMC6235012 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Stem cell reports 20181101 5
Hematopoietic stem and progenitor cells (HSPCs) undergo self-renewal and differentiation to guarantee a constant supply of short-lived blood cells. Both intrinsic and extrinsic factors determine HSPC fate, but the underlying mechanisms remain elusive. Here, we report that Proteinase 3 (PR3), a serine protease mainly confined to granulocytes, is also expressed in HSPCs. PR3 deficiency intrinsically suppressed cleavage and activation of caspase-3, leading to expansion of the bone marrow (BM) HSPC ...[more]