Protein carbamylation in end stage renal disease: is there a mortality effect?

ABSTRACT:

Purpose of review

Protein carbamylation is a posttranslational protein modification caused, in part, by exposure to urea's dissociation product cyanate. Additional modulators of protein carbamylation include circulating free amino acid levels, inflammation, diet, smoking, and environmental pollution exposures. Carbamylation reactions can modify protein charge, structure, and function, leading to adverse molecular and cellular responses. These changes have been linked to several pathologic biochemical pathways relevant to patients with end stage renal disease (ESRD) such as accelerated atherosclerosis and dysfunctional erythropoiesis, among others. This review examines the consequences of human protein carbamylation and the clinical impact this is thought to have in patients with ES

SUBMITTER: Kalim S 

PROVIDER: S-EPMC6235170 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature